(2Z)-3-[3-[3,5-Bis(trifluoromethyl)phenyl]-1H-1,2,4-triazol-1-yl]-2-propenoic acid 2-(2-pyrazinyl)hydrazide
Selinexor (KPT-330)
CAS: 1393477-72-9
Molecular Formula: C17H11F6N7O
(2Z)-3-[3-[3,5-Bis(trifluoromethyl)phenyl]-1H-1,2,4-triazol-1-yl]-2-propenoic acid 2-(2-pyrazinyl)hydrazide - Names and Identifiers
| Name | Selinexor (KPT-330) |
| Synonyms | KPT-330 Aloradine Selinexor KPT330,Selinexor KPT-330,Selinexor Selinexor (KPT-330) (Z)-3-(3-(3,5-bis(trifluoromethyl)phenyl)-1H-1,2,4-triazol-1-yl)-N'-(pyrazin-2-yl)acrylohydrazide (2Z)-3-[3-[3,5-Bis(trifluoromethyl)phenyl]-1H-1,2,4-triazol-1-yl]-2-propenoic acid 2-(2-pyrazinyl)hydrazide 2-Propenoic acid, 3-[3-[3,5-bis(trifluoromethyl)phenyl]-1H-1,2,4-triazol-1-yl]-, 2-(2-pyrazinyl)hydrazide, (2Z)- |
| CAS | 1393477-72-9 |
(2Z)-3-[3-[3,5-Bis(trifluoromethyl)phenyl]-1H-1,2,4-triazol-1-yl]-2-propenoic acid 2-(2-pyrazinyl)hydrazide - Physico-chemical Properties
| Molecular Formula | C17H11F6N7O |
| Molar Mass | 443.31 |
| Density | 1.55±0.1 g/cm3(Predicted) |
| Solubility | Soluble in DMSO (up to at least 25 mg/ml). or in Ethanol (up to at least 25 mg/ml) |
| Appearance | solid |
| Color | Off-white |
| pKa | 9.74±0.43(Predicted) |
| Storage Condition | -20°C |
| Stability | Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 2 months. |
| Physical and Chemical Properties | Bioactive Selinexor (KPT-330, ATG-010) is an orally bioavailable selective CRM1 inhibitor. Phase 2. |
| Target | Target Value CRM1 (Cell-free assay) |
| In vitro study | KPT-330, as a clinical candidate for KPT-185, has a similar effect on the survival of T-ALL cells and rapidly triggers an apoptotic response. KPT-330 also reduced MOLT-4,Jurkat,HBP-ALL,KOPTK-1,SKW-3, and DND-41 cell line growth with an IC50 of 34-203 nM. |
| In vivo study | In vivo, KPT-330 significantly inhibited the growth of T-ALL cells (MOLT-4) and AML cells (MV4-11), with little toxicity to normal hematopoietic cells. KPT-330 treatment of SCID mice with diffuse human multiple myeloma (MM) bone lesions inhibits MM-induced osteolysis and prolongs life. In addition, KPT-330 directly impaired osteoclast formation and bone resorption by inhibiting RANKL-induced NF-κB and NFATc1, with minimal effects on osteoblasts and BMSCs. |
(2Z)-3-[3-[3,5-Bis(trifluoromethyl)phenyl]-1H-1,2,4-triazol-1-yl]-2-propenoic acid 2-(2-pyrazinyl)hydrazide - Upstream Downstream Industry
(2Z)-3-[3-[3,5-Bis(trifluoromethyl)phenyl]-1H-1,2,4-triazol-1-yl]-2-propenoic acid 2-(2-pyrazinyl)hydrazide - Preparation solution concentration reference
| 1mg | 5mg | 10mg | |
|---|---|---|---|
| 1 mM | 2.256 ml | 11.279 ml | 22.558 ml |
| 5 mM | 0.451 ml | 2.256 ml | 4.512 ml |
| 10 mM | 0.226 ml | 1.128 ml | 2.256 ml |
| 5 mM | 0.045 ml | 0.226 ml | 0.451 ml |
Last Update：2024-01-02 23:10:35
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Product Name: KPT-330,Selinexor Visit Supplier Webpage Request for quotationCAS: 1393477-72-9
Tel: +86-18821248368
Email: Int06@meryer.com
Mobile: +86-18821248368
QQ: 495145328
WhatsApp: +86-18821248368
Multiple SpecificationsSpot supply
Product Name: KPT-330 Visit Supplier Webpage Request for quotationCAS: 1393477-72-9
Tel: 609-228-6898
Email: sales@medchemexpress.com
tech@medchemexpress.com
Mobile: 609-228-6898
Spot supply
Product Name: Selinexor Visit Supplier Webpage Request for quotationCAS: 1393477-72-9
Tel: +16314854226
Email: info@bocsci.com
Mobile: +16314854226
Linkedin: https://www.linkedin.com/company/boc-sciences
Product List: View Catalog
Spot supply
Product Name: KPT-330 Visit Supplier Webpage Request for quotationCAS: 1393477-72-9
Tel: +86-400-900-4166
Email: product@acmec-e.com
Mobile: +86-18621343501
QQ: 2881950922
Wechat: 18621343501
WhatsApp: +86-18621343501
Spot supply
Product Name: Selinexor (KPT-330) Visit Supplier Webpage Request for quotationCAS: 1393477-72-9
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
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View History
(2Z)-3-[3-[3,5-Bis(trifluoromethyl)phenyl]-1H-1,2,4-triazol-1-yl]-2-propenoic acid 2-(2-pyrazinyl)hydrazide
1-[4-(2,2-二氯环丙基)苯基]-1-乙酮
1-[4-(2,2-二氯环丙基)苯基]-1-乙酮
Raw Materials for (2Z)-3-[3-[3,5-Bis(trifluoromethyl)phenyl]-1H-1,2,4-triazol-1-yl]-2-propenoic acid 2-(2-pyrazinyl)hydrazide
3,5-Bis(trifluoromethyl)benzonitrile
2-Hydrazinopyrazine
3,5-DI(TRIFLUOROMETHYL)BENZENE-1-CARBOTHIOAMIDE
(Z)-3-(3-(3,5-bis(trifluoroMethyl)phenyl)-1H-1,2,4-triazol-1-yl)acrylic acid
3,5-Di(trifluoromethyl)benzamide
(Z)-isopropyl 3-(3-(3,5-bis(trifluoromethyl)phenyl)-1H-1,2,4-triazol-1-yl)acrylate
2-Hydrazinopyrazine
3,5-DI(TRIFLUOROMETHYL)BENZENE-1-CARBOTHIOAMIDE
(Z)-3-(3-(3,5-bis(trifluoroMethyl)phenyl)-1H-1,2,4-triazol-1-yl)acrylic acid
3,5-Di(trifluoromethyl)benzamide
(Z)-isopropyl 3-(3-(3,5-bis(trifluoromethyl)phenyl)-1H-1,2,4-triazol-1-yl)acrylate
Downstream Products for (2Z)-3-[3-[3,5-Bis(trifluoromethyl)phenyl]-1H-1,2,4-triazol-1-yl]-2-propenoic acid 2-(2-pyrazinyl)hydrazide